Underutilization of isoniazid drug therapy to prevent TB disease progression in Swaziland

Cronin, B., Calnan, M., Haumba, S., & Adams, L. V. (2015). Underutilization of isoniazid drug therapy to prevent TB disease progression in Swaziland. Annals of Global Health, 81(1), 5.

An estimated 80% of the Swaziland population unknowingly contract tuberculosis (TB) as children and harbor inactive TB bacteria in their bodies – a condition called latent TB infection (LTBI). The TB infection can reactivate to cause TB disease in these individuals during their lifetime, especially if they are immunosuppresed by HIV (in Swaziland 75-80% of HIV patients also have latent TB infection). Swaziland has the highest TB incidence rate of any country in the world and TB causes an estimated 50% of the nation’s HIV patient deaths.

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